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Permanent link (DOI): https://doi.org/10.7939/R30X2X

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Giardiasis in children attending daycare centers in Guatemala and the therapeutic potential of ganglioside Open Access

Descriptions

Other title
Subject/Keyword
Giardiasis
Ganglioside
Malnutrition
Daycare centers
Anthropometrics
Guatemala
Children
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Duffy, Terri-Lynn
Supervisor and department
Clandinin, MT (Agricultural, Food & Nutritional Science)
Belosevic, Mike (Biological Sciences)
Solomons, Noel W. (Center for Studies of Sensory Impairment, Aging and Metabolism)
Examining committee member and department
Solomons, Noel W. (Center for Studies of Sensory Impairment, Aging and Metabolism)
Mazurak, Vera (Agricultural, Food & Nutritional Science)
Belosevic, Mike (Biological Sciences)
Clandinin, MT (Agricultural, Food & Nutritional Science)
Department
Department of Agricultural, Food, and Nutritional Science
Specialization

Date accepted
2011-04-07T14:53:09Z
Graduation date
2011-06
Degree
Master of Science
Degree level
Master's
Abstract
Intestinal enteropathy is a prevalent yet neglected aspect of child malnutrition involving chronic exposure to intestinal pathogens such as Giardia intestinalis. Gangliosides have therapeutic potential for the treatment of giardiasis and intestinal enteropathy. The objectives of the thesis were to 1. assess the Giardia carriage patterns in daycares in Guatemala, 2. compare anthropometric data between Giardia carriers and non-carriers, 3. compare sensitivity and specificity of 3 Giardia diagnostic methods (ProSpecT-Giardia-EZ-Microplate assay, RidaQuick Giardia dipsticks and microscopic analysis using the sucrose concentration gradient method). Giardia prevalence rates were high (close to 44%), most cases of infection were chronic (5-week study period), and malnutrition (lower weight-for-age Z-scores) may be associated to higher intensity of infection. ELISA was the most sensitive Giardia diagnostic test. Compared to ELISA, the microscopic and dipstick analysis had sensitivities of 53.6% and 60.7%, and specificities of 100% and 97.9%, respectively, within a set of 75 stool samples.
Language
English
DOI
doi:10.7939/R30X2X
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File format: pdf (Portable Document Format)
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File size: 11687174
Last modified: 2015:10:12 16:07:39-06:00
Filename: Duffy_TerriLynn_Spring_2011.pdf
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File title: TLD_University of Alberta
File author: Terri-lynn Duffy
Page count: 169
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