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Permanent link (DOI): https://doi.org/10.7939/R3P261

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Freshwater Sponges Have Functional, Sealing Epithelia with High Transepithelial Resistance and Negative Transepithelial Potential Open Access

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Author or creator
Adams, E.D.M.
Goss, G.G.
Leys, S.P.
Additional contributors
Subject/Keyword
genes
septate junctions
Demosponge suberites-domuncula
organization
complexity
evolution
glass sponges
insights
calcareous sponges
cell-adhesion
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Epithelial tissue — the sealed and polarized layer of cells that regulates transport of ions and solutes between the environment and the internal milieu — is a defining characteristic of the Eumetazoa. Sponges, the most ancient metazoan phylum [1], [2], are generally believed to lack true epithelia [3], [4], [5], but their ability to occlude passage of ions has never been tested. Here we show that freshwater sponges (Demospongiae, Haplosclerida) have functional epithelia with high transepithelial electrical resistance (TER), a transepithelial potential (TEP), and low permeability to small-molecule diffusion. Curiously, the Amphimedon queenslandica sponge genome lacks the classical occluding genes [5] considered necessary to regulate sealing and control of ion transport. The fact that freshwater sponge epithelia can seal suggests that either occluding molecules have been lost in some sponge lineages, or demosponges use novel molecular complexes for epithelial occlusion; if the latter, it raises the possibility that mechanisms for occlusion used by sponges may exist in other metazoa. Importantly, our results imply that functional epithelia evolved either several times, or once, in the ancestor of the Metazoa.
Date created
2010
DOI
doi:10.7939/R3P261
License information
Rights
© 2010 Adams et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation for previous publication
Adams, E. D. M., Goss, G. G., & Leys, S. P. (2010). Freshwater Sponges Have Functional, Sealing Epithelia with High Transepithelial Resistance and Negative Transepithelial Potential. (B. S. Launikonis, Ed.) PLoS ONE, 5(11), 7.
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