Characterisation of novel potential phosphorylation sites in the tumour suppressor Merlin in Drosophila Open Access
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- Degree grantor
University of Alberta
- Author or creator
- Supervisor and department
Hughes, Sarah (Medical Genetics)
- Examining committee member and department
Campbell, Shelagh (Biological Sciences)
Yokota, Toshifumi (Medical Genetics)
Wevrick, Rachel (Medical Genetics)
Eisenstat, David (Pediatrics)
Medical Sciences-Medical Genetics
- Date accepted
- Graduation date
Master of Science
- Degree level
Neurofibromatosis Type II is an inherited cancer that manifests as various tumours in the nervous system. Mutations and deletions in the tumour suppressor Merlin (moesin, ezrin, radixin-like protein) are linked to the development of the disease. The mechanism by which Merlin suppresses cell growth is not yet clearly understood, however studies have shown that phosphorylation plays an important role in regulating the sub-cellular localisation, conformation, and activity of Merlin. Using in vivo genetic methods in Drosophila melanogaster, I undertook a characterisation of two novel potential phosphorylation sites that appear to be regulating Merlin function.
In this thesis, I show that two phosphorylatable residues, serine 371 and threonine 18, in Drosophila Merlin affect the sub-cellular localisation and function of the Merlin protein.
- Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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