CMOS Instrumentation for Genetic Analysis Lab-on-a-Chip

• Author / Creator

  Martin, Benjamin R

• One application for lab-on-a-chip (LOC) devices is performing miniaturized laboratory
  tests. These devices would be ideal for point-of-care medical diagnostic
  applications; however, many still rely on external bench-top instrumentation. It is
  logical to shrink this instrumentation as well.
  In this dissertation we discuss a mixed-signal CMOS implementation of the
  instrumentation for a genetic analysis LOC. Many genetic analysis methods rely
  on the detection of faint fluorescent signals and the use of high voltages. For this
  reason, special attention is given to the design of the photodiode amplifiers and
  analog-to-digital converter in a 5V/300V 800nm CMOS process.
  As part of this work, we have demonstrated a 2nd-order delta-sigma modulator
  with a bandwidth of 1.2kHz, and an SNR of 78dB. Also, we present a novel
  differential fluorescent detection scheme for capillary electrophoresis that uses two
  photodiodes to dynamically remove the baseline signal caused by excitation light.

• Subjects / Keywords

  • Lab-on-a-chip
  • Capillary Electrophoresis

• Graduation date

  Spring 2012

• Type of Item

  Thesis

• Degree

  Master of Science

• DOI

  https://doi.org/10.7939/R38W38D04

• License

  This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.