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Permanent link (DOI): https://doi.org/10.7939/R38W38D04

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CMOS Instrumentation for Genetic Analysis Lab-on-a-Chip Open Access

Descriptions

Other title
Subject/Keyword
Capillary Electrophoresis
Lab-on-a-chip
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Martin, Benjamin R
Supervisor and department
Elliott, Duncan (ECE Department)
Gaudet, Vincent (Electrical and Computer Engineering Department, now at Waterloo)
Examining committee member and department
Doucette, John (Mechanical Engineering)
Moez, Kambiz (Electrical and Computer Engineering Department)
Department
Department of Electrical and Computer Engineering
Specialization
Integrated Circuits and Systems
Date accepted
2011-12-22T10:00:25Z
Graduation date
2012-06
Degree
Master of Science
Degree level
Master's
Abstract
One application for lab-on-a-chip (LOC) devices is performing miniaturized laboratory tests. These devices would be ideal for point-of-care medical diagnostic applications; however, many still rely on external bench-top instrumentation. It is logical to shrink this instrumentation as well. In this dissertation we discuss a mixed-signal CMOS implementation of the instrumentation for a genetic analysis LOC. Many genetic analysis methods rely on the detection of faint fluorescent signals and the use of high voltages. For this reason, special attention is given to the design of the photodiode amplifiers and analog-to-digital converter in a 5V/300V 800nm CMOS process. As part of this work, we have demonstrated a 2nd-order delta-sigma modulator with a bandwidth of 1.2kHz, and an SNR of 78dB. Also, we present a novel differential fluorescent detection scheme for capillary electrophoresis that uses two photodiodes to dynamically remove the baseline signal caused by excitation light.
Language
English
DOI
doi:10.7939/R38W38D04
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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