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Permanent link (DOI): https://doi.org/10.7939/R34050

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Instrumentation for Interstitial Photodynamic Therapy of Prostatic Carcinoma Open Access

Descriptions

Other title
Subject/Keyword
Real-Time Monitoring
Porstate Cancer
Oscillations
Switched Delivery
Intra-Arterial
Hypocrellin
Photodynamic Therapy
Pulsed Delivery
Dosimetry
Interstitial
Spectral Detection
Fractionated Light Delivery
PDT
SL-052
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Liu, Weiyang
Supervisor and department
Tulip, John (Electrical and Computer Engineering)
Examining committee member and department
Moore, Ronald B. (Surgery)
Tsui, Ying (Electrical and Computer Engineering)
Department
Department of Electrical and Computer Engineering
Specialization

Date accepted
2010-01-19T21:18:31Z
Graduation date
2010-11
Degree
Master of Science
Degree level
Master's
Abstract
This thesis encompasses the development and testing of an interstitial photodynamic therapy (iPDT) system for the treatment of prostate cancer. It begins with the optical characterization of a novel photosensitizer (SL-052) followed by a study of tissue optics as it applies to iPDT. The design and integration of a time-fractionated light delivery system with real-time spectral detection is then examined. An optical phantom test medium is formulated and in vitro system operation and testing is performed. Finally, in vivo experiments are performed on animal models with a focus on canine prostate iPDT. Unique optical results with dosimetric relevance are discovered and investigated. This includes metrics for optically measuring local in vivo SL-052 concentrations in real-time as well as novel oscillatory drug photobleaching and recovery behavior during time-fractionated light delivery.
Language
English
DOI
doi:10.7939/R34050
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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