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PLGA-based nanoparticles for targeting of dendritic cells in cancer immunotherapy and immunomonitoring Open Access


Other title
cancer vaccines
cancer immunomonitoring
dendritic cells
mannose recepror targeting
PLGA nanoparticles
Type of item
Degree grantor
University of Alberta
Author or creator
Ghotbi, Zahra
Supervisor and department
Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
Examining committee member and department
Suresh, Mavanur (Faculty of Pharmacy and Pharmaceutical Sciences)
Kaur, Kamaljit (Faculty of Pharmacy and Pharmaceutical Sciences)
Uludag, Hasan (Department of Chemical and Materials Engineering)
Faculty of Pharmacy and Pharmaceutical Sciences

Date accepted
Graduation date
Master of science
Degree level
Cancer vaccines have shown little success in clinic. Dendritic cells (DCs) are of particular interest in cancer vaccination due to their role in cell-mediated immunity. Active targeting of DCs, through PLGA nanoparticles (PLGA-NPs) decorated with ligands for DC-expressed mannose receptor (MR) can enhance internalization, processing and presentation of antigens and subsequent immnuostimulation. In this study we have shown PLGA-NPs decorated with mannan and the synthetic hydrophobized mannan, especially those with covalent attachment, can target DCs leading to increased uptake of nanoparticles and DC maturation. This approach may be used for improved delivery of antigens and adjuvants to DCs and development of more efficient cancer vaccines. Moreover, significant progress in cancer vaccination requires immunomonitoring. Live imaging using a Positron Emission Tomography (PET) probe encapsulated in PLGA-NPs can elucidate dynamics of recruitment and fate of DCs to develop successful vaccines. The PET-nanoprobe prepared by radio-iodinated 5-IDFPdR demonstrated uncontrolled high burst release implying low quality images.
License granted by Zahra Ghotbi ( on 2010-02-03 (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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