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Permanent link (DOI): https://doi.org/10.7939/R39K46199

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Investigating the Conformational Dynamics of Biomolecules using Optical Tweezers Open Access

Descriptions

Other title
Subject/Keyword
Optical Tweezers
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Soong, JingChyuan
Supervisor and department
Woodside, Michael (Physics)
Examining committee member and department
Tuszynski, Jack (Physics)
LeBlanc, Lindsay (Physics)
Davis, John (Physics)
Department
Department of Physics
Specialization

Date accepted
2014-05-07T15:53:05Z
Graduation date
2014-11
Degree
Master of Science
Degree level
Master's
Abstract
The structural dynamics of proteins and nucleic acids play a vital role in biochemical reactions. We employed novel optical tweezers to study the programmed -1 ribosomal frameshifting, where the conformational plasticity of a SARS pseudoknot with a bound ligand is shown to be correlated to the frameshifting efficiency. We also investigated a mechanical model for components involved in optical tweezers, and tested their validity through a series of measurements.
Language
English
DOI
doi:10.7939/R39K46199
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Dustin B. Ritchie, Jingchyuan Soong, William K. A. Sikkema, and Michael T. Woodside, “Anti-frameshifting Ligand Reduces the Conformational Plasticity of the SARS Virus Pseudoknot”, Journal of the American Chemical Society 2014 136 (6), 2196-2199

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