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Permanent link (DOI): https://doi.org/10.7939/R3XS7T

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Theses and Dissertations

The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience Open Access

Descriptions

Other title
Subject/Keyword
fear
hippocampus
memory
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
McEown, Kristopher
Supervisor and department
Treit, Dallas (Psychology)
Examining committee member and department
Winship, Ian (Psychiatry)
Colbourne, Fred (Psychology)
Sturdy, Chris (Psychology)
Department
Department of Psychology
Specialization

Date accepted
2009-06-02T22:12:38Z
Graduation date
2009-11
Degree
Master of Science
Degree level
Master's
Abstract
This thesis examined the effects of temporary inactivation of the dorsal or ventral hippocampus on unconditioned and conditioned fear, using the shock-probe test. Rats received either dorsal or ventral hippocampal infusions of Lidocaine, muscimol or saline, before or after exposure to an electrified shock-probe. A retention test in the same apparatus was given 24 hr later, at which time the hippocampus was no longer inactivated, and the probe was disconnected from the shock-source. We found that ventral hippocampal inactivation impaired fear behaviour during acquisition, and dorsal hippocampal inactivation impaired fear behaviour during retention. We conclude that the: 1) ventral hippocampus mediates unconditioned fear behaviour, 2) the dorsal hippocampus mediates fear memory and 3) afferent input from brain structures located outside of the hippocampus are not responsible for the differential effects of dorsal and ventral hippocampal inactivation on fear and memory.
Language
English
DOI
doi:10.7939/R3XS7T
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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