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Comparing contact investigations of tuberculosis cases among the Canadian Born Aboriginal and non-Aboriginal population in Alberta, Canada Open Access


Other title
public health
preventive therapy
contact investigation
First Nations
Type of item
Degree grantor
University of Alberta
Author or creator
Eisenbeis, Lisa M
Supervisor and department
Long, Richard (Medicine)
Examining committee member and department
Meardi, Melanie (Nursing)
Yacoub, Wadieh (Medicine)
Verma, Geetika (Medicine)
Department of Medicine
Experiemental Medicine
Date accepted
Graduation date
Master of Science
Degree level
It is well established that the rates of tuberculosis (TB) among Aboriginal Peoples in Alberta are disproportionately higher than those in the Canadian-born 'other' population group (Jensen, Lau, Langlois-Klassen, et al., 2012). In addition, Aboriginal Peoples living on-reserve have higher rates still than those Aboriginal Peoples living off-reserve. Multiple factors likely contribute to this ongoing disparity. One possible reason for the difference in rates between these population groups is the relative success of contact investigations (CI) for source cases from these groups. This possibility has not been addressed systematically in the literature. A contact investigation is the activity undertaken to find and assess individuals who have come into contact with an infectious or potentially infectious TB case. The aim of CI is to identify secondary cases as well as those latently infected individuals who have not yet progressed to disease and in whom disease may be prevented. There are multiple types of contact investigations, including the concentric circle approach which has been used in the Province of Alberta, Canada. Contact investigation is widely accepted as a high-priority activity for TB programs in low incidence areas. Herein I describe a 10-year retrospective study of the contact investigation activities of adult (>14 yrs), Canadian-born, culture positive pulmonary TB cases in Alberta to identify: 1) differences in the outcomes of those activities among Aboriginal Peoples living on and off-reserve, as compared to Canadian-born 'others'. It is anticipated that any differences found between these groups will shed light on the potential for improvement of contact investigation in Alberta specific to the population group of the source case, and 2) to determine predictors of successful CI in each population group. This knowledge has the potential to provide guidance for TB programs based on those predictors.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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