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Exploring the Use of Nuclear Magnetic Resonance to Examine Spinal Cord Injury Open Access


Other title
Spinal Cord Injury
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Type of item
Degree grantor
University of Alberta
Author or creator
Hallihan, Daniel P
Supervisor and department
Mushahwar, Vivian (Division of Physical Medicine and Rehabilitation)
Allen, Peter (Biomedical Engineering)
Examining committee member and department
Thompson, Richard (Biomedical Engineering)
Fouad, Karim (Rehabilitation Medicine)
Department of Biomedical Engineering

Date accepted
Graduation date
Master of Science
Degree level
Spinal cord injury is most commonly caused by physical trauma, and the resulting functional loss can vary considerably in both degree, extent and location. Understanding what spinal cord tissue is damaged and to what degree can be useful in both determining the appropriate treatment for individuals with spinal cord injury and for assessing novel methods of treatment. This thesis looks at the applications of nuclear magnetic resonance (NMR), to assess spinal cord injury, assess the effects of various treatments and assist in developing new treatments of spinal cord injury. The treatment of interest in this thesis is intra-spinal micro-stimulation (ISMS), a method of functional electrical stimulation (FES). Magnetic resonance imaging (MRI) provided grey/white matter contrast in images and ISMS micro-wire localization, water compartmentalization showed promise in determining myelination, and nuclear magnetic resonance spectroscopy (MRS) found several metabolites that varied due to spinal cord injury and could potentially be measured in-vivo.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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