ERA

Download the full-sized PDF of Dual role of matrix metalloproteinases-2 in thoracic aortic aneurysmDownload the full-sized PDF

Analytics

Share

Permanent link (DOI): https://doi.org/10.7939/R3RR1PV80

Download

Export to: EndNote  |  Zotero  |  Mendeley

Communities

This file is in the following communities:

Graduate Studies and Research, Faculty of

Collections

This file is in the following collections:

Theses and Dissertations

Dual role of matrix metalloproteinases-2 in thoracic aortic aneurysm Open Access

Descriptions

Other title
Subject/Keyword
Extracellular matrix
Aortic aneurysm
Matrix metalloproteinases
vascular remodeling
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Lee, Ji Won
Supervisor and department
Kassiri, Zamaneh (Physiology)
Examining committee member and department
McMurtry, Sean (Medicine)
Fernandez-Patron, Carlos (Biochemistry)
Davidge, Sandra (Obstetrics & Gynaecology)
Department
Department of Physiology
Specialization

Date accepted
2013-12-09T11:16:03Z
Graduation date
2014-06
Degree
Master of Science
Degree level
Master's
Abstract
With matrix metalloproteinases-2 (MMP2) deficiency, we observed thoracic aortic aneurysm in 70% of MMP2-/- mice but no abdominal aortic aneurysm following four weeks of angiotensin II (Ang II) infusion. We found markedly suppressed recoil properties in the thoracic aorta of MMP2-/-- Ang II mice. mRNA and protein levels of elastin, but not collagen, were significantly reduced in the thoracic aorta of MMP2-/--Ang II compared to WT-Ang II mice. This reduction in elastin levels was due to significantly reduced TGFβ-Smad signaling pathway that mediates synthesis of extracellular components. Thus, the adverse remodeling in the thoracic aorta of MMP2-deficient mice was associated with decreased synthesis of extracellular matrix proteins without concomitant upregulation of proteolytic activities. These findings suggest a protective role of MMP2 in the development and progression of aortic aneurysm, and as such inhibition of MMP2 may exacerbate vascular remodeling and lead to development of thoracic aortic aneurysm.
Language
English
DOI
doi:10.7939/R3RR1PV80
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication

File Details

Date Uploaded
Date Modified
2014-06-15T07:09:42.118+00:00
Audit Status
Audits have not yet been run on this file.
Characterization
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 2977399
Last modified: 2015:10:12 15:42:09-06:00
Filename: Lee_Ji_Spring 2014.pdf
Original checksum: 1e3db232f3a21e256f8d3cf4f3b62ff8
Well formed: true
Valid: true
File author: Jiwon Candella
Page count: 136
File language: en-CA
Activity of users you follow
User Activity Date