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Existence of endothelial progenitor cells with self-renewal and clonogenic potential in normal human placenta and preeclampsia Open Access


Other title
human placenta
endothelial progenitor cells
micro vasculature
endothelial colony forming cells
macro vasculature
Type of item
Degree grantor
University of Alberta
Author or creator
Garbacea, Ioana
Supervisor and department
Thebaud, Bernard ( Paediatrics)
Examining committee member and department
Yoder, Mervin (Department of Paediatrics)
Cheung, Po-Yin ( Department of Paediatrics)
Davidge, Sandra (Departments of Obstetrics/Gynecology and Physiology)
Medical Sciences-Paediatrics

Date accepted
Graduation date
Master of Science
Degree level
Preeclampsia (PE) is the leading cause of maternal death in developing countries. PE is defined as hypertension and proteinuria after 20 weeks of gestation. The only curative treatment is placental delivery. Evidence suggests that placental vasculature is disturbed with shallow invasion of maternal arteries. We hypothesize that the function of a particular type of EPCs - endothelial colony forming cells (ECFCs) are impaired in PE. ECFCs were isolated from macro vasculature of normotensive and PE placentas. ECFCs robustly expressed CD31, CD105, CD144, CD146 and were negative for CD14 and CD45. PE-ECFCs formed less complex structures on Matrigel and gave rise to lower numbers of high proliferative potential colonies upon single cell plating compared to normotensive controls. ECFCs exist in the human placenta. The function of PE-ECFCs is disturbed. Our data provides new insight into the pathophysiology of PE and the role of ECFCs.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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