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Permanent link (DOI): https://doi.org/10.7939/R3Z390

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Characterization of Aerosol Deposition in Children and Infants Using Idealized Extrathoracic Geometries Open Access

Descriptions

Other title
Subject/Keyword
idealized geometries
in vitro
children
pharmaceutical aerosol
infants
deposition
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Ruzycki, Conor A.
Supervisor and department
Finlay, Warren H. (Mechanical Engineering)
Examining committee member and department
FInlay, Warren H. (Mechanical Engineering)
Vehring, Reinhard (Mechanical Engineering)
Martin, Andrew (Mechanical Engineering)
Department
Department of Mechanical Engineering
Specialization

Date accepted
2014-09-22T14:58:31Z
Graduation date
2014-11
Degree
Master of Science
Degree level
Master's
Abstract
This thesis describes a number of experimental studies performed with the common goal of characterizing pharmaceutical aerosol deposition in children and infants using idealized extrathoracic geometries. First, an in vitro study of the recently proposed Alberta Idealized Child Throat showed that this idealized child oral extrathoracic airway model accurately replicates average deposition of pharmaceutical aerosol from pressurized metered dose inhalers and dry powder inhalers in school age children. This successful validation confirms that the Alberta Idealized Child Throat may indeed fulfill the existing requirement for a standardized platform in which benchtop testing of delivery devices and therapeutic formulations developed for children can be examined. Second, a joint in vitro – in silico methodology was employed to characterize deposition in an idealized infant nasal extrathoracic airway geometry. Using a novel flow system, total lung dose from two pressurized metered dose inhalers, delivered via valved holding chamber and facemask under a realistic breath profile, was approximated by the dose delivered distal to the idealized geometry. In silico simulations using this estimate of total lung dose provided insight on regional deposition in the lungs and on the concentration of drug in the airway surface liquid. From a clinical perspective, this in vitro – in silico methodology provides valuable guidance on the dosing required for efficacious use of aerosolized medications in infants. Finally, a comparison of in vitro deposition measured in two idealized geometries representative of the oral extrathoracic airways of children is described, illustrating the importance of considering the physics governing aerosol behavior in the human airways when developing idealized geometries meant to mimic in vivo deposition. It is hoped that the experiments undertaken as part of this thesis will aid in the development of new delivery devices and inhalation therapies for the treatment of disease in children and infants.
Language
English
DOI
doi:10.7939/R3Z390
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Ruzycki, C. A., L. Golshahi, R. Vehring, and W. H. Finlay. 2014. "Comparison of In Vitro Deposition of Pharmaceutical Aerosols in an Idealized Child Throat with in Vivo Deposition in the Upper Respiratory Tract of Children." Pharmaceutical Research 31 (6): 1525-1535. Publisher: Springer Science + Business Media 2014Finlay, W. H., C. A. Ruzycki, L. Golshahi, and R. Vehring. 2014. "Validating and Scaling the Alberta Idealized Child Throat." Respiratory Drug Delivery 2014 1: 303-310. Publisher: Virginia Commonwealth University / RDD Online 2014

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