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Permanent link (DOI): https://doi.org/10.7939/R3Z09Z

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Vitamin D Supplementation and Bone Health in Adults with Diabetic Nephropathy: Preliminary Findings from a Randomized Controlled Trial Open Access

Descriptions

Other title
Subject/Keyword
Chronic Kidney Disease
Diabetes
Bone Health
RCT
Vitamin D
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Schwindt, Stephanie T
Supervisor and department
Mager, Diana (Agricultural, Food, and Nutritional Science)
Examining committee member and department
Field, Catherine (Agricultural, Food, and Nutritional Science)
Senior, Peter (Medicine)
McCargar, Linda (Agricultural, Food, and Nutritional Science)
Department
Department of Agricultural, Food, and Nutritional Science
Specialization
Nutrition and Metabolism
Date accepted
2013-08-29T11:13:26Z
Graduation date
2013-11
Degree
Master of Science
Degree level
Master's
Abstract
Vitamin D (vitD) is a nutrient of concern in Canada particularly for those with diabetes and chronic kidney disease (CKD). Participants (18-80y) with diabetes and CKD were randomized to receive either 50mcg/day (n=33) or 1,000mcg/month (n=30) vitD3 for 6-months. Variables studied included: anthropometric/demographic data, routine clinical blood work, serum/plasma 25(OH)D, 1,25(OH)2D, PTH, bone turnover markers (BTM), and vitD intake. No significant differences in clinical characteristics between groups or study visits were observed (p>0.05). Adherence to daily and monthly supplementation was 93% and 100%, respectively. Mean 25(OH)D and 1,25(OH)2D concentrations increased in both groups after 6-months; but significant increases in 25(OH)D were seen only in the daily group (78.4 to 95.1nmol/L; p=0.01). There were no significant differences between groups over 6-months in PTH or BTM (p>0.05). This suggests that both once daily and once monthly vitD supplementation strategies are equally effective at influencing vitD status despite differences in adherence.
Language
English
DOI
doi:10.7939/R3Z09Z
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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