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Permanent link (DOI): https://doi.org/10.7939/R3VQ2SK0R

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VLSI Design and System Integration for a USB Genetic Amplification Platform Open Access

Descriptions

Other title
Subject/Keyword
lab-on-a-chip
VLSI
polymerase chain reaction
genetic amplification
microfluidic system
biomedical
USB
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Ho, Sunny
Supervisor and department
Elliott, Duncan (Electrical and Computer Engineering)
Backhouse, Christopher (Electrical and Computer Engineering)
Examining committee member and department
Joseph, Dileepan (Electrical and Computer Engineering)
Sanders, Sean (Chemical and Materials Engineering)
Department
Department of Electrical and Computer Engineering
Specialization
Biomedical Engineering
Date accepted
2012-05-31T12:35:16Z
Graduation date
2011-11
Degree
Master of Science
Degree level
Master's
Abstract
We demonstrate the feasibility of USB-powered portable genetic amplification. One of the central processes within medical or biological genetic methods is polymerase chain reaction (PCR). Through this amplification, more quantities of the specified genetic target can be obtained for analysis and testing. In this work we have designed a system that is able to perform PCR using a Universal Serial Bus (USB) link for power and communications. The significance of this is the portability and accessibility that comes with the USB based platform. The system is built around a custom VLSI CMOS chip which was designed to accommodate the functionalities required to perform PCR. The intended design and shortcomings of the VLSI chip, as well as characterization and optimization of the system will be discussed in this thesis. This work also includes the design and testing of system firmware, system integration, and demonstration of PCR through molecular diagnostic lab work.
Language
English
DOI
doi:10.7939/R3VQ2SK0R
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File title: Microsoft Word - Chapter 2 Formatted.doc
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