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Permanent link (DOI): https://doi.org/10.7939/R3SH6F

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In vitro hematopoietic stem/progenitor cell proliferation and labeling Open Access

Descriptions

Other title
Subject/Keyword
Hematopoietic stem/progenitor cell
labeling/tracking
in vtiro proliferation
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Xu, Peng
Supervisor and department
Dr.Jie Chen (ECE&BME)
Examining committee member and department
Dr. Jie Chen (ECE&BME)
Dr.Hasan Uludag (CME&BME)
Dr.Jame Xing (Laboratory medicine and pathology)
Department
Department of Biomedical Engineering
Specialization

Date accepted
2011-04-07T21:14:50Z
Graduation date
2011-06
Degree
Master of Science
Degree level
Master's
Abstract
Hematopoietic stem/progenitor cells (HSPC) play main role in constituting the whole hematopoietic system. Furthermore, since recognized in 1960s, HSPC are utilized to protect patients from severe chemo and radio therapy. As time goes, they are also used to treat hematopoietic disorders such as leukemia. Bone marrow, peripheral blood and umbilical cord blood are now the three sources of HSPC. Umbilical cord blood seems optimal because it is easy to obtain, no risk to graft donor and low probability of infection transmission. However, low number of HSPCs in umbilical cord blood is the main limitation. My research focuses mainly on in-vitro proliferation of HSPCs. In addition, I also worked on labeling HSPC in-vitro for tracking these cells after transplantation. The experimental results indicated that HSPCs are effectively labeled and their proliferation rate is significantly enhanced in-vitro.
Language
English
DOI
doi:10.7939/R3SH6F
Rights
License granted by Peng Xu (px1@ualberta.ca) on 2011-04-06T22:46:01Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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