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Permanent link (DOI): https://doi.org/10.7939/R3TH0G

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Elevated Fatty Acid Content in Muscle is Prevented by EPA and DHA in an Animal Model of Colorectal Cancer Receiving CPT-11 / 5-FU Open Access

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Other title
Subject/Keyword
Colorectal Cancer
Sarcopenia
Essential Fatty Acids
Skeletal Muscle
EPA and DHA
Cachexia
irinotecan / 5-fluorouracil
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Almasud, Alaa A
Supervisor and department
Mazurak, Vera (Agricultural, Food and Nutritional Science)
Examining committee member and department
Putman, Ted (Exercise Physiology and Biochemistry)
Baracos, Vickie (Oncology and Agricultural, Food and Nutrition Science)
Mazurak, Vera (Agricultural, Food and Nutritional Science)
Clandinin, Thomas (Agricultural, Food and Nutritional Science)
Department
Department of Agricultural, Food, and Nutritional Science
Specialization
Nutrition and Metabolism
Date accepted
2012-08-15T07:51:47Z
Graduation date
2012-11
Degree
Master of Science
Degree level
Master's
Abstract
This study aimed to assess the effect of irinotecan / 5-fluorouracil treatment on amount and types of fatty acids in skeletal muscles of tumor-bearing rats fed: a) control diet, b) fish oil diet. Rats bearing the Ward colorectal carcinoma were fed a semi-purified diet with or without fish oil prior to receiving chemotherapy. Gastrocnemius muscles were isolated 7 days later. Lipids were extracted and triglycerides (TG) and phospholipid (PL) separated by thin layer chromatography, and fatty acids (FAs) quantified by gas liquid chromatography. Rats receiving chemotherapy exhibited the most TG-FA in muscle tissue. Rats fed the fish oil diet exhibited lower total muscle TG compared with other groups. N-3 FA content in muscle TG and PL were higher in the fish oil group compared to other groups. This study suggests that fish oil modifies the fat accumulation in muscle that occurs during chemotherapy.  
Language
English
DOI
doi:10.7939/R3TH0G
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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