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A role for Polycomb Repressive Complex 2 in the DNA damage response Open Access


Other title
DNA damage
Type of item
Degree grantor
University of Alberta
Author or creator
Campbell, Stuart D.
Supervisor and department
Hendzel, Michael (Oncology)
Examining committee member and department
Underhill, Alan (Oncology)
Weinfeld, Michael (Oncology)
Schultz, Michael (Biochemistry)
Department of Oncology
Experimental Oncology
Date accepted
Graduation date
Master of Science
Degree level
Polycomb protein methyltransferase, Enhancer of Zeste 2 (Ezh2), is frequently overexpressed in human malignancy and is implicated in cancer cell proliferation and invasion. Recently, several other polycomb proteins have been implicated in modulating the response to DNA double strand breaks, and thus we hypothesize that Ezh2 is also involved in the DNA damage response pathway. We investigated the involvement of Ezh2 and its associated complex, polycomb repressive complex 2 (PRC2), in the DNA damage response pathway. We found that PRC2 proteins recruit to sites of DNA damage and knockdown of Ezh2 decreases double strand break repair efficiency and increases cellular sensitivity to ionizing radiation. Our data supports the hypothesis that PRC2 is involved in the DNA damage response and contributes to DNA double strand break signaling and repair.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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