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Permanent link (DOI): https://doi.org/10.7939/R3GW2X

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Effect of gastric bypass and gastric banding on lipid absorption and their influence on glucose metabolism Open Access

Descriptions

Other title
Subject/Keyword
Obesity
Insulin resistance
Gastric banding
Apolipoprotein B48
Lipid metabolism
Gastric bypass
Lipid absorption
Plasma lipids
Bariatric surgery
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Vizhul, Andrey
Supervisor and department
Birch, Daniel W. (Surgery)
Lehner, Richard (Pediatrics)
Examining committee member and department
Churchill, Thomas A. (Surgery)
Sharma, Arya M. (Medicine)
Department
Department of Surgery
Specialization

Date accepted
2011-08-22T16:26:38Z
Graduation date
2011-11
Degree
Master of Science
Degree level
Master's
Abstract
Roux-en-Y gastric bypass (RYGB) leads to sustainable weight loss and resolution of hyperlipidemia and type 2 diabetes in obese patients. Its hypolipidemic effect is presumed to be based on fat malabsorption. Comparison of lipid absorption and insulin resistance following RYGB with adjustable gastric banding (AGB) and medical treatment clarifies the importance of the bypassing aspect of RYGB. The presented work is a cross-sectional study of 48 matched obese patients following RYGB, AGB and medical treatment, whose plasma lipids, glucose and insulin were analyzed after a lipid meal. The results of the study demonstrate that postprandial triglycerides, apolipoprotein B48 and nonesterified fatty acids are lower following RYGB compared with AGB and medical treatment. The accelerated disposal of plasma triglycerides and chylomicrons is associated with normalized insulin sensitivity and this can be a key mechanism in the improvement of lipid metabolism after RYGB, which supports its indications in obese hyperlipidemic and diabetic patients.
Language
English
DOI
doi:10.7939/R3GW2X
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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Last modified: 2015:10:12 20:41:51-06:00
Filename: Thesis Andrey Vizhul Lipids RYGB final.pdf
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File title: Thesis AV2 1_FINAL_RL corrected
File author: Andrey Vizhul
Page count: 116
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