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Permanent link (DOI): https://doi.org/10.7939/R3201V

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The Effects of a Western Diet on Stroke Severity and Functional Outcome Following Global Ischemia in Rats Open Access

Descriptions

Other title
Subject/Keyword
High fat western diet
Morris water maze task
Stroke
Hippocampus
Global Ischemia
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Arvanitidis, Anastasia P
Supervisor and department
Colbourne, Fred (Psychology, Neuroscience)
Examining committee member and department
Todd, Kathryn (Neuroscience)
Sturdy, Chris (Psychology)
Treit, Dallas (Psychology)
Department
Department of Psychology
Specialization

Date accepted
2009-07-02T19:14:39Z
Graduation date
2009-11
Degree
Master of Science
Degree level
Master's
Abstract
The present thesis investigated the effects of a western diet (WD) on cell death and functional outcome following global ischemia in rats. Experiment 1 assessed the effects of a 60-day WD regimen on temperature, activity and glucose levels in normal rats. Experiment 2 evaluated the influence of a 60-day WD regimen on hippocampal CA1 injury and cognition following global ischemia. Results from experiment 1 revealed significant differences in activity levels only; animals fed the WD were less active than control diet animals. Results from experiment 2 suggested that a WD did not aggravate CA1 injury or behavioral deficits. The second portion of my thesis examined the effects of a 120-day WD regimen on stroke severity and cognition following global ischemia. Briefly, the surgical protocol used to induce a global ischemic insult did not produce consistent damage across all animals. Plausible reasons for this surgical variability and future directions are discussed.
Language
English
DOI
doi:10.7939/R3201V
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File title: Table of Contents
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