ERA

Journal Articles (Pharmacy)

Number of results to display per page
Items in this Collection
  1. Pulmonary delivery of inhalable nanoparticles: dry powder inhalers [Download]

    Title: Pulmonary delivery of inhalable nanoparticles: dry powder inhalers
    Creator: Al-Hallak, MHD Kamal
    Subjects: Inhalable dry powders, Pulmonary delivery
    Date Created: 2011
  2. Effervescent dry powder for respiratory drug delivery [Download]

    Title: Effervescent dry powder for respiratory drug delivery
    Creator: Ely, Leticia
    Subjects: Ciprofloxacin, Inhalable dry powders, Drug delivery, Nanoparticles, Aerosol, Spray drying, Pulmonary delivery, Effervescent
    Date Created: 2007
  3. Computer simulations using GastroPlus™ to justify a biowaiver for etoricoxib solid oral drug products [Download]

    Title: Computer simulations using GastroPlus™ to justify a biowaiver for etoricoxib solid oral drug products
    Creator: Okumu, Arthur
    Subjects: In-silico, BCS, Bioequivalence, Permeability, IVIVC, Etoricoxib
    Date Created: 2009
  4. Poly n-butylcyanoacrylate (PNBCA) nanocapsules as a carrier for NSAIDs: in vitro release and in vivo skin penetration [Download]

    Title: Poly n-butylcyanoacrylate (PNBCA) nanocapsules as a carrier for NSAIDs: in vitro release and in vivo skin penetration
    Creator: Miyazaki, S.
    Description: Abstract: Purpose: The aim of this work was to prepare poly n-butylcyanoacrylate (PNBCA) nanocapsules loaded with indomethacin and to evaluate the ability of this carrier system to deliver the drug systemically after its topical application. Methods: Poly n-butylcyanoacrylate (PNBCA) nanocapsules of indomethacin were prepared by interfacial polymerization. The physicochemical characterization of the PNBCA nanocapsules was performed by measuring the drug content by HPLC and analyzing the particle size using scanning electron microscopy. The in vitro permeation of indomethacin through excised rat skin and an artificial membrane was determined for PNBCA nanocapsules in pH 7.4 phosphate buffer (1), and in PLF-127 gel (II) and were compared against indomethacin incorporated into 25%w/w Pluronic F-127 (PLF-127) gel alone (III). The in vivo percutaneous absorption of indomethacin following the application of the PNBCA nanocapsules and a 25%w/w PLF-127 gel (111) was monitored by the determination of drug plasma levels in rats. RESULTS: The drug loading results indicated that similar to76.6% of indomethacin was loaded onto the PNBCA nanocapsules; the average particle size was 188 nm. The in vitro results indicated a rank order for the three formulations (1, II and 111) in both the flux at steady state and the cumulative amounts permeated at 8 hrs. The higher drug plasma levels over 6 hrs of indomethacin PNBCA nanocapsules are in agreement with the determined in vitro permeation results. Conclusion: The presented data show that indomethacin loaded PNBCA nanocapsules can improve the transdermal delivery of indomethacin compared to a conventional gel formulation using Pluronic F-127. This might be due to their ultra fine particle size and their hydrophilic and hydrophobic surface characteristics.
    Subjects: Indomethacin, Polybutylcyanoacrylate nanoparticles, Pharmaceutical application, Loaded nanoparticles, Poly(isobutylcyanoacrylate), Pluronic F-127 gels, Tissue distribution, Biomedical polymers, Drug-delivery, Polyalkylcyanoacrylate nanoparticles
    Date Created: 2003
  5. Effervescent inhalable nanoparticles for treating lung cancer [Download]

    Title: Effervescent inhalable nanoparticles for treating lung cancer
    Creator: Azarmi, S.
    Description: This is an abstract of a presentation made at the conference titled \"The Aerosol Society Drug Delivery to the Lungs 20,\" at the Edinburgh International Conference Centre, Scotland, UK, December 9-11, 2009.
    Subjects: Lung cancer, Abstracts, Nanoparticles
    Date Created: 2010
  6. Investigation of vitamin and mineral tablets and capsules on the Canadian market [Download]

    Title: Investigation of vitamin and mineral tablets and capsules on the Canadian market
    Creator: Löbenberg, R.
    Description: Abstract: PURPOSE: The goal of this study was to investigate the disintegrating properties of tablets and capsules containing minerals and vitamins commercially available on the Canadian market and to review their label information. METHODS: The labels were examined for product-related information. The first disintegration test stage was performed using Simulated Intestinal Fluid (SIF) pH 6.8 for 20 minutes. Products which did not disintegrate were further investigated using USP disintegration conditions for dietary supplements. RESULTS: The provided label information is difficult to understand and in some cases pseudo-scientific. Thirty out of thirty-nine tablets and six out of ten capsules had a Drug Identification Number ( DIN). Twenty-one of thirty-nine tablets and four out of the ten capsules did not disintegrate within 20 minutes. Using the USP disintegration conditions for dietary supplements nine tablet products did not fully disintegrate but all capsules passed the test. None of the three \"time-released\" products disintegrated under the applied conditions. CONCLUSIONS: Industry should follow already existing label recommendations more closely to allow the consumers to make an informed decision on their products by providing only essential information rather than using pseudo-scientific terms. The results of the disintegration study indicated that disintegration, one of the most basic quality control parameters, is still a concern for dietary supplements.
    Subjects: Delivery, Intestinal calcium-absorption, Transport, Mechanical destructive force
    Date Created: 2006
  7. Macrophage Targeting of Azidothymidine: A Promising Strategy for AIDS Therapy [Download]

    Title: Macrophage Targeting of Azidothymidine: A Promising Strategy for AIDS Therapy
    Creator: Löbenberg, R.
    Description: Abstract: Macrophages play an important role in the immunopathogenesis of AIDS, The objective of this study was to investigate the possibility of specific targeting of antivirals such as azidothymidine (AZT) to macrophages, using nanoparticles as a colloidal drug carrier, The body distribution of AZT bound to nanoparticles and as a control solution was studied in rats after intravenous and peroral administration, C-14-Labeled AZT was bound to nanoparticles in the presence of bis(2-ethylhexyl)sulfosuccinate sodium, The radioactivity was measured in different organs including those containing large numbers of macrophages. After intravenous injection, the concentrations of AZT were up to 18 times higher in organs belonging to the reticuloendothelial system (RES) when the drug was bound to nanoparticles than after injection of an aqueous AZT solution, Likewise, after oral administration the nanoparticle formulation delivered AZT more efficiently to the RES than the aqueous solution, In addition, the blood concentration was significantly higher after oral administration of nanoparticles. These results demonstrate that nanoparticles are a promising drug-targeting system for AZT to the RES organs. The increase in drug availability at the sites containing abundant macrophages may allow a reduction in dosage to avoid systemic toxicity.
    Subjects: Liposomes, Human-immunodeficiency-virus, Delivery, Drug, Monocytes, Infection, Nanoparticles
    Date Created: 1996
  8. Biorelevant dissolution media as a predictive tool for glyburide a class II drug [Download]

    Title: Biorelevant dissolution media as a predictive tool for glyburide a class II drug
    Creator: Wei, Hai
    Subjects: Computational simulation, IVIVC, Solubility, Dynamic dissolution, Permeability, Prediction, In vitro dissolution, In vitro/in silico, Biorelevant dissolution media (BDM), Oral drug absorption
    Date Created: 2006
  9. Lipocalin-2: pro- or anti-apoptotic? [Download]

    Title: Lipocalin-2: pro- or anti-apoptotic?
    Creator: Kehrer, James P.
    Description: Survival and apoptosis signaling pathways are altered concomitantly in response to numerous endogenous and exogenous stressors. The lipocalin family of small soluble proteins has been implicated in modulating apoptosis. However, the overall effect of these proteins has been variable, showing both proand anti-apoptotic activities. The goal of this minireview is to summarize the studies on lipocalins and apoptosis and consider what roles lipocalin-2 may play in cell death and survival.
    Subjects: 24p3, Apoptosis, Neutrophil gelatinase-associated lipocalin (NGAL), Lipocalin-2, Signaling
    Date Created: 2010
  10. Formulation and in vivo evaluation of effervescent inhalable carrier particles for pulmonary delivery of nanoparticles [Download]

    Title: Formulation and in vivo evaluation of effervescent inhalable carrier particles for pulmonary delivery of nanoparticles
    Creator: Azarmi, Shirzad
    Subjects: Effervescent, Nanoparticle, Cyanoacrylate, Carrier particles, Pulmonary delivery
    Date Created: 2008